Osmosis Jones

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Osmosis Jones

PG

2001

1h 38m

Kids & Family

Comedy

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Tomatometer

Popcornmeter

55%

Tomatometer

111 Reviews

42%

Popcornmeter

50,000+ Ratings

A cutting-edge, live action/animated action adventure comedy about one white blood cell's (Chris Rock) race against the biological clock to hunt down and destroy a lethal new virus (Laurence Fishburne). Bill Murray stars as Frank, in whose body the action unfolds.

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Critics Consensus

The animated portion of Osmosis is zippy and fun, but the live-action portion is lethargic.

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Nell Minow

Common Sense Media

Mostly animated PG film has gross-out humor, violence.

Rated: 3/5

Dec 26, 2010

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Time Out

The plot's so much old rote, and the characters have all the personality of protoplasm; but the anthropomorphising of this microcosmic metropolis is wonderfully imaginative, and the dialogue decidedly spiffy.

Jan 26, 2006

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Kimberley Jones

Austin Chronicle

The ideas are there, hints of genius, but no one ignites them.

Rated: 2/5

Mar 10, 2003

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Dan DiNicola

The Daily Gazette (Schenectady, NY)

It's imaginative, ingenious and dramatically flat. Still, it may satisfy his who will learn a lot about the nasty effects of junk food on the human body.

Rated: C+

Apr 30, 2024

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Korey Coleman

Double Toasted

It sometimes lets its imagination cut loose in a fun way. But a lot of the movie is just puns, body humor, jokes...but some of the parts, they do very well with it...

May 11, 2020

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Erik Anderson

AwardsWatch

...one of the smartest, funniest and most eye-popping films of the year.

Rated: 3.5/4

Apr 7, 2020

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Noel L

This was Rush Hour in the human body. It was so cringy and disgusting for a majority of the film for how graphic and real it gets

Rated 1 out of 5 stars

11/10/25

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Audience Member

Criminally underrated. The animation is amazing, and this movie has one of the best cartoon villains I’ve ever seen. Thrax is fantastic antagonists. Great character design, voice acting, animation, etc. I do prefer the animated portions of the movie over the live-action ones, but the two tie together to make one cohesive story. The overall story is fairly basic, but the setting for the events that unfold is unique and keeps an otherwise basic plot feeling fresh.

Rated 5 out of 5 stars

09/01/25

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CHARLOTTE B

i cant find a movie mother suckers

Rated 1 out of 5 stars

06/12/25

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Hex x

Enjoyable movie, especially for kids.

Rated 3.5 out of 5 stars

04/30/25

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shrek d

i'll be puffin like diddy

Rated 0.5 out of 5 stars

03/31/25

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Amir S

A reasonable but interesting film, in a strange way it reminds me of the film "Saw 9".

Rated 3 out of 5 stars

03/26/25

Full Review

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Peter Farrelly

Director

Robert Farrelly

Director

Bill Murray

Frank

Molly Shannon

Mrs. Boyd

Chris Elliott

Bob

Elena Franklin

Shane Detomello

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Synopsis

A cutting-edge, live action/animated action adventure comedy about one white blood cell's (Chris Rock) race against the biological clock to hunt down and destroy a lethal new virus (Laurence Fishburne). Bill Murray stars as Frank, in whose body the action unfolds.

Director: Peter Farrelly, Robert Farrelly
Producer: Peter Farrelly, Robert Farrelly, Bradley Thomas, Zak Penn, Dennis Edwards
Screenwriter: Marc Hyman
Distributor: Warner Bros. Pictures
Production Co: Warner Brothers, Conundrum Entertainment
Rating: PG (Bodily Humor)
Genre: Kids & Family, Comedy
Original Language: English
Release Date (Theaters): Aug 10, 2001, Wide
Release Date (Streaming): Dec 3, 2007
Box Office (Gross USA): $13.6M
Runtime: 1h 38m
Sound Mix: Dolby SR, DTS, Dolby Stereo, Surround, SDDS, Dolby A, Dolby Digital
Aspect Ratio: Scope (2.35:1)

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