Caroline Rhea ("Sabrina the Teenage Witch") hosts "Caroline & Friends: The Game" which features two contestants who try to predict the audience's reaction to hilarious and heartwarming viewer-submitted videos. Contestants compete with each other to predict the audience's response with the help of Rhea's celebrity friends, including Kim Coles, Mo Collins, John Henson, Jaleel White, and others. Whoever can best predict the audience's response with the help of Caroline's celebrity friends will play for a cash prize.