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Season 1 – Common Side Effects

Play trailer 1:09 Poster for Season 1 – Common Side Effects Next Ep Sun Mar 23 Comedy Mystery & Thriller Play Trailer Watchlist
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Two former high school lab partners stumble on a mushroom that can heal almost anything, apart from the corporate interests of the DEA, big pharma, and international businessmen.
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Common Side Effects — Season 1

Common Side Effects — Season 1

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Critics Consensus

An addictive mix of expressive animation, heady concepts, and an offbeat sense of humor, Common Side Effects is a must-have prescription.

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Critics Reviews

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Judy Berman TIME Magazine But for all its big names and ambitious themes, Common Side Effects feels, in the best way possible, like the kind of indie-animation oddity you might‘ve stumbled upon at 3 a.m. on ‘90s MTV. Mar 4, 2025 Full Review Ben Travers IndieWire The show usurps expectations for good reason -- and for a reason fairly common to classic conspiracy stories: to get us to rethink the way the world works. Hopefully, before it’s too late. Feb 14, 2025 Full Review Angie Han The Hollywood Reporter Wherever it goes, the result, for now, is a series that feels not quite like anything else on television. It’s unpredictable and genuinely exciting. Feb 14, 2025 Full Review Alise Chaffins Loud and Clear Reviews You might not expect an Adult Swim animated show to be the one that brings nuance to this dialogue, but Common Side Effects seems to have discovered the cure for that kind of binary thinking. Rated: 4.5/5 Mar 12, 2025 Full Review Chris Gallardo Tell-Tale TV From magnetic, empathetic characters to that brooding music to the exquisite visuals, this series proves its potential as one of the best adult animated series of all time. Rated: 4.25/5 Mar 4, 2025 Full Review Nick Valdez ComicBook.com Common Side Effects is teasing a much larger mystery at play that’s going to draw you in each and every week. It’s the kind of show that’s really going to sneak up on you. Rated: 4/5 Feb 27, 2025 Full Review Read all reviews

Audience Reviews

View All (27) audience reviews
Erik N This is actually pretty good. Seems like anything Mike Judge gets involved with turns out well. Rated 5 out of 5 stars 03/16/25 Full Review m s Yawwwwn! I was there for 90s adult swim and 3am animated Mtv. This ain't it. I tried twice and couldn't finish the pilot. Vice on youtube is far more entertaining, and that's a low bar. Rated 1 out of 5 stars 03/12/25 Full Review Michael L Honestly had really high hopes for this series and it flopped terribly. The animation is nothing special, and the story has such huge holes in it that it's not worth giving it the benefit of the doubt the first episode tries way to hard and literally only makes sense if you are on mushrooms or drugs and even then I'd rather watch anything else. The main character is literally every junkie on the planet hoping they are the main character some how and I truly do believe the only reason this is getting such good reviews is because in today's society most people are on drugs. I made an account just to write this review because I'm tired of people recommending this show like it is the best thing since sliced bread. It's not I've watched all the released episodes and it literally can barely hold itself together as a story there are more holes in the plot than swiss cheese. Hope y'all have a lovely day. Rated 1 out of 5 stars 03/11/25 Full Review MANUEL M I can't wait for the next episode. So good! Love it!! Rated 5 out of 5 stars 03/10/25 Full Review Audience Member This series is absolutely fascinating, I am heavily addicted. I wish the episodes were longer and I hope they are planning to make a season 2! Rated 4.5 out of 5 stars 03/08/25 Full Review Rico R This show is absolutely a must watch. The themes are very appropriate for this era we live in. This easily could have been live action on how grounded it is but the animation really works in the benefit of the story Rated 5 out of 5 stars 03/06/25 Full Review Read all reviews
Common Side Effects — Season 1

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Cast & Crew

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Joseph Bennett

Creator

Steve Hely

Creator

Dave King

Marshall Cuso

Emily Pendergast

Frances Applewhite

Mike Judge

Rick Kruger

Martha Kelly

Agent Harrington

Episodes

Episode 1 Aired Feb 2, 2025 Pilot Marshall Cuso shows up in NYC with a mushroom, that can cure any disease or injury; his old classmate, Frances, meets him by chance, but keeps secret that she works for Reutical, a pharmaceutical company. Details Episode 2 Aired Feb 2, 2025 Lakeshore Limited Marshall is on the run, trying to flee New York; Frances confides to her boss, Rick, about the mushroom; Rick sends her to Marshall's farm to get more, but the situation gets out of hand. Details Episode 3 Aired Feb 9, 2025 Hildy Marshall seeks advice from Hildy; Copano and Harrington are drawn further into the mystery. Details Episode 4 Aired Feb 16, 2025 Dumpsite Marshall buys a plot of land near a chemical waste site with a plan to grow more mushrooms; Frances rushes home from Europe after a huge development; Copano and Harrington investigate a connection between Marshall and Frances. Details Episode 5 Aired Feb 23, 2025 Star-Tel-Lite Marshall, Frances, and their crazy neighbors deal with the aftermath of a dangerous incident. Details Episode 6 Aired Mar 2, 2025 In the System Marshall arrives in jail and learns that some very important people refuse to let him out, while danger lurks around every corner; Frances makes a fateful decision; Copano and Harrington pick up the pieces. Details Episode 7 Aired Mar 9, 2025 Blowfish Marshall is rescued by another inmate, but now Marshall owes him a favor; desperate to get out of prison, he works on a risky plan when he runs into a surprising ally; Frances grapples with a life-changing event. Details Episode 8 Aired Mar 16, 2025 Amelia & Wyatt Two former high school lab partners stumble on a mushroom that can heal almost anything, apart from the corporate interests of the DEA, big pharma, and international businessmen. Details Episode 9 Airs Sun Mar 23 Cliff's Edge Two former high school lab partners stumble on a mushroom that can heal almost anything, apart from the corporate interests of the DEA, big pharma, and international businessmen. Details Episode 10 Airs Sun Mar 30 Raid Two former high school lab partners stumble on a mushroom that can heal almost anything, apart from the corporate interests of the DEA, big pharma, and international businessmen. Details
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Common Side Effects — Season 1

Common Side Effects: Season 1 Trailer 2 Common Side Effects: Season 1 Trailer 2 1:09 Common Side Effects: Season 1 Trailer Common Side Effects: Season 1 Trailer 1:30 View more videos
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Common Side Effects — Season 1

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Season Info

Director
Camille Bozec, Sean Buckelew, Benjy Brooke, Vincent Tsui
Creator
Joseph Bennett, Steve Hely
Executive Producer
Sean Buckelew, Greg Daniels, Dustin Davis, James Merrill, Suzanna Makkos, Mike Judge, Steve Hely, Juan Manuel Freire
Screenwriter
Joseph Bennett, Emma Barrie, Steve Hely, Jon Foor, Jean Kyoung Frazier, Dave King
Network
Adult Swim
Rating
TV-14
Genre
Comedy, Mystery & Thriller
Original Language
English
Release Date
Feb 2, 2025