Episode 1
Aired Apr 6, 2021
Sahira is adamant that her father is innocent; Louis discovers Vicky is trapped in a toxic relationship; Lucky feels unsure about whether Kian is really clean.
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Episode 2
Aired Apr 13, 2021
Dominic pushes Sacha to make an illicit choice; Kian and Chloe make a shocking discovery in theatre; the McGerrys reach a breaking point.
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Episode 3
Aired Apr 20, 2021
Louis is trapped as Vicky's blackmailing escalates; Dom tries to convince Ange to take his case on.
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Episode 4
Aired Apr 27, 2021
Sacha prepares to risk everything for Dom, but Ange might be onto them.
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Episode 5
Aired May 4, 2021
The cause of Reyhan's death comes into question, putting Hanssen and Sahira's relationship at breaking point; Dominic's new found optimism might be too much too soon; Kian continues to lie to Lucky.
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Episode 6
Aired May 11, 2021
Donna leads the Holby nursing staff in a protest, but it remains to be seen if Hanssen will be moved by the nurses' cause.
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Episode 7
Aired May 18, 2021
When a majax strikes Holby, a self-harming Hanssen must be heroic enough to ask for help; secret addict Kian must choose between a young patient and Andrei; thrust into the limelight, Jeong must diagnose a mystery condition.
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Episode 8
Aired May 25, 2021
Dom finds out how far he is willing to go to ensure his path to power; Max buries her head in the sand over her BRCA1 diagnosis; reeling from Andrei's sacrifice, Kian may be willing to betray Fletch's trust.
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Episode 9
Aired Jun 1, 2021
It's the day of Max's operation; Ange and Josh's relationship deepens; Kian convinces Andrei to return to the hospital to have his surgery.
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Episode 10
Aired Jun 8, 2021
Kian faces losing Andrei, just when he thought he had got him back; Dom gets a shock when a patient chooses Sacha as her consultant instead of him; Ange and Josh risk losing their jobs over their secret relationship.
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Episode 11
Aired Jun 15, 2021
Sparks fly between Kian and Fletch after Evie and Andrei disappear.
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Episode 12
Aired Jun 22, 2021
Josh questions his place on AAU, and Darwin faces a crisis that could unravel Fletch.
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Episode 13
Aired Jul 5, 2021
Lucky attempts to overcome her personal crisis by throwing herself into her work.
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Episode 14
Aired Jul 7, 2021
The hospital faces an emergency inspection; Josh's mom disapproves of his relationship.
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Episode 16
Aired Jul 20, 2021
Dom is shocked when he discovers Carole's secret; Hanssen is torn as to how to handle Abs's secret; Josh tries to prove to Ange that he's up to the role of being a father.
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Episode 17
Aired Jul 27, 2021
A look into if Holby City's new director of improvement can turn the hospital around.
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Episode 18
Aired Aug 3, 2021
A terminally ill patient advises Kylie to tell Louis how she really feels about him.
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Episode 19
Aired Aug 10, 2021
Holby's new director of improvement becomes furious when Hanssen attempts to block their plans for AAU; Evie finds herself facing an impossible decision; time is running out for Chloe to find a suitable candidate for Eli's medical trial.
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Episode 20
Aired Aug 17, 2021
Evie struggles to cope as she is drawn deeper into Jeni's world; Dom has doubts about mom Carole joining Darwin's stent trial; Kylie must overcome her issues with new nurse Mel for the sake of a desperate young patient.
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Episode 21
Aired Aug 24, 2021
Chloe assists in Eli's experimental stent trial; Donna's teenage daughter Mia arrives drunk on the Holby doorstep after a party with Jeni's dodgy clients.
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Episode 22
Aired Aug 31, 2021
Another of Jeni's girls is admitted with a suspicious cut on her arm.
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Episode 23
Aired Sep 7, 2021
Eli's experimental stent trial looks like it will be over before it's begun when his patient takes a turn for the worse; Ange prepares for the life-saving transfusion on her unborn baby; Lucky uncovers the dark truth behind Jeni's activities.
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Episode 24
Aired Sep 14, 2021
Hanssen finds himself in a dangerous situation; Kylie and Dom suspect an elderly patient may be in peril, and Louis fears for Kylie.
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Episode 25
Aired Sep 21, 2021
Jeni starts making plans to send Evie away; Jac refuses to listen to Max, who insists she starts looking into alternative treatment options for her tumour; new dad Josh may not be coping as well as Ange thinks he is.
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Episode 26
Aired Sep 28, 2021
Fletch confronts Jeni about what she did to Evie; Josh's mom visits unexpectedly; Amelia springs an awkward surprise on Eli.
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Episode 27
Aired Oct 5, 2021
Donna allows her personal life to affect her work and neglects Lucky; Jac and Josh try to win Holby a place on a cutting-edge therapy study, Kylie discovers that Louis and Mel are still together.
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Episode 28
Aired Oct 12, 2021
When Lucky wakes from surgery, Max has to deliver some life-changing news; Josh tries to cope with the pressures of fatherhood and work; Henrik is shocked when a familiar face returns to Holby.
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Episode 29
Aired Oct 19, 2021
Lucky asks Max for an impossible favor; Hanssen reluctantly agrees to mentor a new protégé, despite their shared and painful history; Josh struggles to handle the pressure.
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Episode 30
Aired Oct 26, 2021
On Josh's birthday, a surprise celebration causes him to fall back into dangerous habits; Kylie tries a bold strategy to save Lucky; Russ and Hanssen find themselves locked in a store cupboard together.
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Episode 31
Aired Nov 2, 2021
Ollie tries to contain his deep-seated fears; Josh finds an unexpected reason to take the Green War of the Wards challenge seriously; Max and Kylie must put aside their differences in order to save the planet.
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Episode 32
Aired Nov 9, 2021
Amelia must break some devastating news to husband Eli; Ollie's shady past threatens to catch up with him; forgotten and forsaken Jeong is in desperate need of a friend.
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Episode 33
Aired Nov 16, 2021
Lucky is readmitted to Holby; Louis learns the truth about her suicidal thoughts; Jac falters just as she's about to start the proton-beam therapy; Eli persuades Josh he needs to tell Ange about his bulimia.
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Episode 34
Aired Nov 23, 2021
Russ learns the truth about Ollie's relationship with Maisie; Max and Dom disagree over his diagnosis of a Black female patient.
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Episode 35
Aired Nov 30, 2021
Eli struggles to focus on the ward as he worries about Amelia's health; Russ tries to reassure Hanssen of his responsible nature.
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Episode 36
Aired Dec 7, 2021
Dom remains in denial about Carole's ailing health; Eli and Amelia face a difficult choice; Ollie is eager to return to work, but Hanssen has doubts.
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Episode 38
Aired Jan 4, 2022
With a visit from an inspector expected, Jac hopes a complex operation will show Holby at its best.
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Episode 39
Aired Jan 11, 2022
Dom returns from compassionate leave, but Sacha feels concerned he still needs to recover; Jac potentially prioritizes Holby over her own health; Fletch's faith in her seems misplaced.
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Episode 40
Aired Jan 18, 2022
Eli is compromised ethically when Jac implores him to perform risky surgery on her; Fletch finds himself seriously considering Regina's job offer.
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Episode 41
Aired Jan 25, 2022
As Fletch's faith in Holby is dented, a job offer from St James' becomes increasingly appealing; Hanssen discovers Billie's secret and is reluctant to keep it from her father; Nicky reaches breaking point with Juliet.
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Episode 42
Aired Feb 1, 2022
Jac pushes Nicky to overcome her demons and become the doctor she knows she can be; Donna feels dejected when she repeatedly goes above and beyond but gets no recognition from anyone.
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Episode 43
Aired Feb 8, 2022
Jac's ambitious plans for the hospital nearly push her staff to a breaking point, and Donna struggles to balance it all.
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Episode 44
Aired Feb 15, 2022
Josh is tested when a familiar face is admitted to AAU; Max has her principles pushed to the limit; Eli wrestles with his conscience as Amelia presses him about Juliet's future.
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Episode 45
Aired Feb 22, 2022
Nicky must find the strength to be a mother to Juliet or give away her baby for good; as the hospital is forced to lock down, Hanssen has to help deliver Billie's baby; as AAU handles the Darwin overflow, Ange notices Madge behaving suspiciously.
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Episode 46
Aired Feb 28, 2022
Kylie believes Madge is the victim of domestic abuse, and Dom receives a lucrative offer.
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Episode 47
Aired Mar 8, 2022
Holby struggles to get itself out of special measures; Regina puts more pressure on Madge to betray Jac and the hospital.
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Episode 48
Aired Mar 15, 2022
Fletch makes a last-ditch attempt to find a surgeon to save Jac's life; Kylie tries to persuade Jac to visit Madge at home to find out what is behind her betrayal of Holby.
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Episode 49
Aired Mar 22, 2022
The team operate on Jac to try to save her life; Josh's relationship with Claudia resurfaces; Lexy receives good news about a new kidney.
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Episode 50
Aired Mar 29, 2022
The reverberations of Jac's surgery impact around Darwin and beyond; A wounded Dom feels more left out than ever after learning Josh and Ange have closed him out of their family crises; Donna and Hanssen rally around Lexy after bad news.
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