Christina Applegate returns to TV as Reagan, a successful talk show executive producer who has just had a child with her stay-at-home husband, Chris (Will Arnett). As they adjust to their new life, Reagan and Chris become rattled by self-doubt, sleep deprivation and the pressure of today's parenting protocols. At work, Reagan is constantly reminded of the carefree life she and Chris have traded in for parenthood by her boss and best friend, vulnerable talk show host Ava, who leads a robust social life.